Articles  |   September 2013
SEE Question
Article Information
Airway Management / Cardiovascular Anesthesia / Education / CPD / Obstetric Anesthesia / Pain Medicine / Pharmacology / Respiratory System / Articles
Articles   |   September 2013
SEE Question
ASA Monitor 09 2013, Vol.77, 58.
ASA Monitor 09 2013, Vol.77, 58.
A recent phase I clinical trial reported on the pharmacokinetics of remimazolam, a new benzodiazepine, in normal volunteers. Which of the following is MOST likely true about its characteristics compared to midazolam?
A recent publication reported on the first phase I clinical trial of remimazolam in normal volunteers. Remimazolam is a novel benzodiazepine designed to undergo rapid hydrolysis to inactive metabolites. Like the similarly named remifentanil, remimazolam was designed to be administered by continuous infusion for easily titrated sedation in short surgical cases and procedures.
In this pharmacokinetic study, remimazolam was administered as an intravenous bolus at doses ranging from 0.05 mg/kg to 0.35 mg/kg. Depth of sedation, plasma clearance, and the occurrence of side effects were compared in a double-blind fashion to the known effective dose of midazolam (0.075 mg/kg) and to an inactive placebo. The dose of remimazolam was escalated steadily in successive groups of study patients until the majority of volunteers at the given dose required airway support to preserve ventilation.
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