Articles  |   July 2015
ACE Question
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Education / CPD / Articles
Articles   |   July 2015
ACE Question
ASA Monitor 07 2015, Vol.79, 44.
ASA Monitor 07 2015, Vol.79, 44.
Which statement about anesthetic considerations in a patient with Down syndrome (trisomy 21) is most likely true?
Down syndrome (trisomy 21) is present in 0.1 percent of live births and is associated with several coexisting disorders that affect anesthetic management.
Approximately half of patients with trisomy 21 have hypothyroidism, and congenital heart disease is often present. Lesions common to these patients include tetralogy of Fallot (8 percent), patent ductus arteriosus (12 percent), ventricular septal defect (27 percent) and endocardial cushion defects (40 percent). Although usually asymptomatic, atlanto-occipital instability occurs in about one-sixth of the patients, and it is recommended that these patients be treated with precautions against instability.
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