Articles  |   April 2014
ACE Question
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Education / CPD / Articles
Articles   |   April 2014
ACE Question
ASA Monitor 04 2014, Vol.78, 41.
ASA Monitor 04 2014, Vol.78, 41.
Which statement about 2,3-diphosphoglycerate (2,3-DPG) and banked blood stored for at least 96 hours is most likely true?
The P50 of blood is determined in part by the level of 2,3-diphosphoglycerate (2,3-DPG) in the red blood cells. The presence of 2,3-DPG bound to hemoglobin causes a decrease in the oxygen affinity of hemoglobin, which results in an increased P50 and a rightward shift of the oxyhemoglobin dissociation curve. The P50 of blood can range between 15 mm Hg and 34 mm Hg based on the percentage of hemoglobin molecules containing 2,3-DPG.
Although a substantial amount of research was conducted in an effort to determine ways to increase 2,3-DPG levels to augment oxygen unloading from hemoglobin, it appears that the only circumstance in which 2,3-DPG levels are clinically relevant is in the administration of banked blood.
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